A.  
alcohol
Alcohol, taken even in small amounts; produces a dulling of judgement, 
comprehension and attention, lessened sense of responsibility, a slowing of 
reflexes and reduced coordination, decreases in eye efficiency, increased 
frequency of errors, decrease of memory and reasoning ability, and fatigue.
When a pilot undertakes a flight along a given course from one airport to 
some landing place, hundreds of decisions must be relating to the operation of 
the airplane and the navigational aspects of the flight. Proper procedures must 
be accomplished to effect the safe completion of the flight and to ensure that 
no hazard is created to other airplanes in nearby airspace. Obviously, anything 
that impairs the pilots ability to make decisions will increase accident 
potential.
Alcohol is absorbed very rapidly into the blood and tissues of the body. Its 
effects on the physiology are apparent quite soon after ingestion and wear off 
very slowly. In fact, it takes about 3 hours for the effects of 1 ounce of 
alcohol to wear off. Nothing can speed up this process. Neither coffee nor hard 
exercises nor sleep will minimize the effects of alcohol.
Scientists have recently discovered that alcohol is absorbed into the fluid 
of the inner ear and stays there after it has gone from the blood and brain. 
Since the inner ear monitors; balance, alcohol there can be responsible for 
incorrect balance information and possibly spatial disorientation.
The presence of alcohol in the blood interferes with the normal use of oxygen 
by the tissues (histotoxic hypoxia). Because of reduced pressure at high 
altitudes and the reduced ability of the haemoglobin to absorb oxygen, the effect 
of alcohol in the blood, during flight at high altitudes, is much more 
pronounced than at sea level. The effects of one drink are magnified 2 to 3 
times over the effects the same drink would have at sea level.
A pilot should never carry a passenger that is under the influence of 
alcohol. Such a person's judgment is impaired. His reactions during ascent to 
higher altitudes are unpredictable. He may become belligerent and unmanageable 
and a serious hazard to the safety of the flight.
The rule for both pilot and passengers in relation to alcohol quite simply 
should be "No alcohol in the system when you fly". The Air 
Regulations require that a pilot allow at least 12 hours between the consumption 
of alcohol and piloting an airplane. In fact, more time is probably necessary. 
An excellent rule is to allow 24 hours between the last drink and take-off time. 
The after effects (hangover) of alcohol consumption also affect performance 
capability, causing headache and impairing emotional stability and judgment.
B.  
drugs
Drugs, as well as the conditions for which they are taken, can interfere with 
the efficiency of the pilot and can be extremely dangerous. Even over the 
counter drugs such as aspirin, antihistamines, cold tablets, nasal 
decongestants, cough mixtures, laxatives, tranquillisers and appetite suppressors 
impair the judgment and co-ordination. They are responsible for drowsiness, 
dizziness, blurred vision, confusion, vertigo and mental depression. The effects 
of some drugs are even more pronounced at higher altitudes than on the ground. 
Some over the counter drugs taken in
combination will react with each other resulting in a larger effect than even 
the sum of their individual effects. Some prescription drugs, such as 
antibiotics, are equally or more dangerous. Usually, however, a person sick 
enough to be on antibiotics is too sick to be flying.
Any use of illicit drugs is incompatible with air safety. Even the so-called 
soft drugs affect performance, mood and health.
Anti-histamines  
(For allergic disorders). Cause sedation with varying 
degrees of drowsiness, decreased reaction time, disturbances of equilibrium. Do 
not pilot an airplane within 24 hours of taking an antihistamine.
Sulfa Drugs. Cause visual disturbances, dizziness, impaired reaction 
time, depression. Remain off flying for 48 hours.
Tranquillisers. Affect reaction time, concentration and division of attention. 
U.S. military pilots get grounded for 4 weeks following treatment.
Aspirin. Toxic effects are relatively rare and are almost always 
associated with large doses. If you take aspirin in small dosage and have had no 
reactions in the past, it is probably safe to take it and fly.
Motion Sickness Remedies. Cause drowsiness and depress brain function. 
They cause temporary deterioration of judgment making skills. Do not take either 
prescribed or over the counter motion sickness remedies. If suffering from 
airsickness while piloting an aircraft, open up the air vents, loosen the 
clothing, use supplemental oxygen if available and keep the eyes on a point 
outside the airplane. Avoid unnecessary head movements.
Reducing Drugs. Amphetamines and other appetite suppressing drugs cause 
feelings of well being that affect good judgment.
Barbiturates (including Phenobarbital). Noticeably reduce alertness. Do 
not pilot an airplane within 12 hours of treatment.
Anaesthetics. Following local and general dental and other 
anaesthetics, a 
period of 48 hours should elapse before flying.
      
C.  
blood donations
Because it takes several weeks for the blood circulation to return to normal 
after a blood donation, it is recommended that pilots who are actively flying 
refrain from volunteering as blood donors. If a blood donation has been made, 
you should consult your doctor before flying again.
D.  
fatigue
      
fatigue and 
flight operations
Fatigue is a threat to aviation 
  safety because of the impairments in alertness and performance it creates. "Fatigue" 
  is defined as "a non-pathologic state resulting in a decreased ability 
  to maintain function or workload due to mental or physical stress." The 
  term used to describe a range of experiences from sleepy, or tired, to exhausted. 
  There are two major physiological phenomena that have been demonstrated to create 
  fatigue: sleep loss and circadian rhythm disruption. Fatigue is a normal response 
  to many conditions common to flight operations because of sleep loss, shift 
  work, and long duty cycles. It has significant physiological and performance 
  consequences because it is essential that all flight crew members remain alert 
  and contribute to flight safety by their actions, observations and communications. 
  The only effective treatment for fatigue is adequate sleep (1).
In a National Transportation Safety 
  Board (NTSB) safety study of US major carrier accidents involving flight crew 
  from 1978 to 1990, one finding directly addressed the concern about fatigue. 
  It stated: "Half the captains for whom data were available had been awake 
  for more than 12 hours prior to their accidents. Half the first officers had 
  been awake for more than 11 hours. Crews comprising captains and first officers 
  whose time since awake was above the median for their crew position made more 
  errors overall, and significantly more procedural and tactical decision errors 
  (2)."
An example of fatigue as a probable 
  cause of a US commercial aircraft accident occurred on August 18th, 
  1993 in Guantanamo Bay, Cuba involving a DC-8. The airplane was destroyed by 
  impact forces and post-accident fire, and the three flight crewmembers sustained 
  serious injuries. Visual meteorological conditions prevailed, and an instrument 
  flight rules plan had been filed. The following is the NTSB summary report: 
  
The airplane collided with terrain aprx 1/4 mi from the approach end of 
  the runway after the captain lost control of the airplane. Flightcrew had experienced 
  a disruption of circadian rhythms and sleep loss; had been on duty about 18 
  hrs and had flown aprx 9 hrs. Capt did not recognize deteriorating flightpath 
  and airspeed conditions due to preoccupation with locating strobe light on ground. 
  Strobe light, used as visual reference during approach, inoperative; crew not 
  advised. Repeated callouts by the flight engineer stating slow airspeed conditions 
  went unheeded by the capt. Capt initiated turn from base leg to final at airspeed 
  below calculated vref of 147 kts, and less than 1,000 ft from the shoreline, 
  and he allowed bank angles in excess of 50 deg to develop. Stall warning stick 
  shaker activated 7 secs prior to impact, 5 secs before airplane reached stall 
  speed. No evidence to indicate capt attempted to take proper corrective action 
  at the onset of stick shaker. Operator's management structure and philosophy 
  were insufficient to maintain vigilant oversight and control of the rapidly 
  expanding airline operation. 
Probable Cause 
The impaired judgement, 
  decision-making, and flying abilities of the captain and flightcrew due to the 
  effects of fatigue; the captain's failure to properly assess the conditions 
  for landing and maintaining vigilant situational awareness of the airplane while 
  manoeuvring onto final approach; his failure to prevent the loss of airspeed 
  and avoid a stall while in the steep bank turn; and his failure to execute immediate 
  action to recover from a stall. Additional factors contributing to the cause 
  were the inadequacy of the flight and duty time regulations applied to 14 cfr, 
  part 121, supplemental air carrier, international operations, and the circumstances 
  that resulted in the extended flight/duty hours and fatigue of the flightcrew 
  members. Also contributing were the inadequate crew resource management training 
  and the inadequate training and guidance by the airline, to the flightcrew for 
  operations at special airports, such as Guantanamo bay; and the navy's failure 
  to provide a system that would assure that the local tower controller was aware 
  of the inoperative strobe light so as to provide the flightcrew with such information. 
  
(NTSB REPORT AAR-94/04, 
  ADOPTED 5/10/94)
When the sleep patterns of this 
  flight crew were analyzed it was found that the entire flight crew suffered 
  from cumulative sleep loss. They worked under an extended period of continuous 
  wakefulness, and slept at times opposite to their normal circadian sleep patterns. 
  The accident occurred in the afternoon, at the time of their maximum physiological 
  sleepiness (2). 
sleep and sleep loss
Sleep is a vital physiological function. 
  Like food and water, sleep is necessary for survival. Sleepiness results when 
  sleep loss occurs. Like hunger and thirst, sleepiness is the brain's signal 
  that sleep is needed. "Sleep loss" describes the phenomenon of getting 
  less sleep than is needed for maximal waking performance and alertness. If an 
  individual normally needs 8 hours of sleep to feel completely alert, and gets 
  only 6 hours of sleep, 2 hours of sleep loss has been incurred. Sleep loss over 
  successive days accumulates into a "sleep debt." If the individual 
  needing 8 hours of sleep gets only 6 hours a night for 4 nights in a row, an 
  8 hours sleep debt has been accumulated. The negative effects of one night of 
  sleep loss are compounded by subsequent sleep loss. Sleep loss and the resultant 
  sleepiness can degrade most aspects of human performance. In the laboratory, 
  it has been demonstrated that losing as little as 2 hours of sleep can negatively 
  affect alertness and performance. Performance effects include: degraded judgment, 
  situation awareness, decision-making, and memory; slowed reaction time; lack 
  of concentration; fixation; and worsened mood. Other effects are decreased work 
  efficiency, degraded crew coordination, reduced motivation, decreased vigilance, 
  and increased variability of work performance. The brain is programmed for two 
  periods of maximal sleepiness every 24 hours from about 3 
  - 5 am and 3 - 5 pm (3). 
symptoms and effect of 
fatigue
Conditions which contribute to fatigue 
  include the time since awake, the amount of time doing the task, sleep debt, 
  and circadian rhythm disruption. As fatigue progresses it is responsible for 
  increased errors of omission, followed by errors of commission, and microsleep. 
  "Microsleep" is characterized by involuntary sleep lapses lasting 
  from a few seconds to a few minutes (3). For obvious reasons, errors or "short 
  absences" can have significant hazardous consequences in the aviation environment.
Many of the unique characteristics 
  of the flight deck environment make pilots particularly susceptible to fatigue. 
  Contributing aircraft environmental factors include movement restriction, variable 
  air flow, low barometric pressure and humidity, noise, and vibration. In commercial 
  aircraft, hands on flying has been mostly replaced by greater demands on the 
  flight crew to perform vigilant monitoring of multiple flight systems. Research 
  has demonstrated that monotonous vigilance tasks decreased alertness by 80% 
  in one hour (4). This phenomenon is often referred to as "boredom fatigue." 
  
Fatigue and sleepiness may be less 
  evident to a pilot due to stimuli such as noise, physical activity, caffeine, 
  nicotine, thirst, hunger, excitement, and interesting conversation. Sleep-deprived 
  pilots may not notice sleepiness or other fatigue symptoms during preflight 
  and departure flight operations. However once underway and established on altitude 
  and heading, sleepiness and other fatigue symptoms tend to manifest themselves. 
  
When extreme, fatigue can cause 
  uncontrolled and involuntary shutdown of the brain. That is, regardless of motivation, 
  professionalism, or training, an individual who is extremely sleepy can lapse 
  into sleep at any time, despite the potential consequences of inattention. Transportation 
  incidents and accidents, such as the one cited above, provide dramatic examples 
  of this fact.
circadian 
rhythms 
"Circadian rhythms" are 
  physiological and behavioural processes, such as sleep/wake, digestion, hormone 
  secretion, and activity, that oscillate on a 25 hour basis. Each rhythm has 
  a peak and a low point during every day/night cycle. Time cues, called "zeitgebers," 
  keep the circadian "clock" set to the appropriate time of day. Common 
  zeitgebers include daylight, meals and work/rest schedules. If the circadian 
  clock is moved to a different schedule, for example when crossing time zones 
  or changing from a day work shift to a night shift, the resulting "sleep 
  phase shift" requires a certain amount of time to adjust to the new schedule. 
  This amount of time depends on the number of hours the schedule is shifted, 
  and the direction of the shift. During this transition, the circadian rhythm 
  disruption or "jet lag" can produce effects similar to those of sleep 
  loss. 
Transmeridian flights in excess 
  of three time zones can result in significant circadian rhythm disruption. When 
  flying in a westerly direction the pilots day is lengthened. When flying 
  east, against the direction of the sun, the pilots day is shortened. Thus 
  the physiological time and local time can vary by several hours. Symptoms of 
  jet lag are usually worse when flying from west to east as the day is artificially 
  shortened. It takes about one day for every time zone crossed to recover from 
  jet lag. When circadian disruption and sleep loss occur together, the adverse 
  effects of each are compounded (3).
crew rest and flying duties
Scheduling of adequate crew rest 
  needs to take several important factors into consideration. These include time 
  since awake, time on task, type of tasks, extensions of normal duty periods, 
  and cumulative duty times (3).
The "time since awake" 
  is the starting point for fatigue to build. This can be prolonged prior to flying 
  due to the effects of jet lag, early awakening due to disturbances in the sleep 
  environment, the extra time needed to get up check out of a hotel and travel 
  to the airport for flight check in, and delays in getting started preflight 
  procedures including for mechanical problems or weather delays. "Time on 
  task" is the time required to preflight and fly. This is the time from 
  check-in to block-in plus fifteen minutes on the last flight of the day. The 
  "type of tasks" depend on the crew position, type of aircraft, and 
  the nature of the flights. Extensions of normal duty periods can occur from 
  events which prolong the flight longer than scheduled. Such events include delays 
  for en route weather, rerouting due to traffic or, more rarely, diversions. 
  Research on duty period duration suggests that duty periods greater than twelve 
  hours are associated with a higher risk of errors. In determining maximum limits 
  for extended duty periods, consideration needs to be given to all factors which 
  contribute to fatigue including the numbers of legs in the days flight 
  plan, whether jet lag is a factor in the crew duty day, and the time since awake. 
  "Cumulative duty times" are most fatiguing when there are consecutive 
  flying days with minimal or near minimal crew rest periods. This can result 
  in sleep debt which requires additional time to overcome (3). 
A brief review of US Federal Aviation 
  Administration (FAA) flight time and rest rules for scheduled domestic commercial 
  carriers (US Code Title 14, part 121.471) are as follows:
  Crewmember total flying time 
    maximum of: 
  
  
  Rest for scheduled flight 
    during the 24 hours preceding the completion of any flight segment:  
    
      - 
      9 hours rest for less than 
        8 hours scheduled flight time 
- 
      10 hours rest for 8 hours 
        or more but less than 9 scheduled flight time 
- 
      11 hours rest for 9 hours 
        or more scheduled flight time 
The flight crew duty day starts 
  with check-in, and is considered concluded at block-in plus 15 minutes for that 
  days final flight. Rest periods are times when the crewmember is not scheduled 
  for flying duty. These are not periods of restful sleep. Adequate restful sleep, 
  however, must be achievable during these rest periods. In addition to FAA regulations, 
  company rules and practices also influence crew scheduling and rest issues. 
  Company contracts with pilots, scheduling practices for bids and reserve, and 
  productivity demands all play a part in the balance between work requirements 
  and crew rest. 
restful sleep requirements
There is considerable variability 
  in individual sleep needs. Some individuals do well with 6 hours sleep per night, 
  yet others need 9 or 10 hours sleep. However, most adults require 8 hours of 
  restful sleep to stay out of sleep debt. With aging there is usually a significant 
  decline in habitual daily sleep due to increased nighttimes awakenings. Therefore, 
  in older individuals decreased quality of night time sleep can result in increased 
  daytime fatigue, sleepiness, dozing and napping (5) (6). Napping seems to compensate 
  for the loss of quality sleep during night time hours, but the need for a mid-day 
  nap may not be compatible with flight duty demands on short haul flights (3). 
  Research has demonstrated that pre-planned cockpit rest has improved in-flight 
  sustained attention and psychomotor response speed (7). Some international airlines 
  have created policies allowing pilots to nap during long haul flights at times 
  of low workloads. Thus far, the US Federal Aviation Regulations have not made 
  reference to planned in-flight crew rest.
Complete recovery from significant 
  sleep debt may not occur after a single sleep period. Usually 2 nights of recovery 
  are required. Eight to 10 hours of recovery sleep per sleep period may be required 
  for most people to achieve effective levels of alertness and performance (8). 
  Obtaining the required sleep time under layover conditions depends on the length 
  of the off duty rest period. Off duty time must be adequate to allow for at 
  least 8 hours of restful sleep per night in order to recover from sleep debt, 
  and therefore the potentially hazardous effects of flying while fatigued.
conclusion and 
recommendations
Pilot fatigue has been shown to 
  be a hazard in commercial flight operations. Many factors contribute to fatigue 
  in the commercial aviation environment. Circadian rhythm disruption, prolonged 
  work schedules, inadequate crew rest, and inadequate restful sleep contribute 
  to the potential for pilot fatigue. When the regulations regarding "rest" 
  are compared to identified requirements for "restful sleep," one can 
  see that adequate restorative rest may not occur. Reviews of federal research 
  activities, hours of service/rest regulations, and airline company scheduling 
  policies are needed to correct existing systemic problems. Enhanced pilot training 
  is also needed to prevent fatigue, and to recognize it when it occurs so that 
  effective countermeasures can be employed (1). Doing so will help insure that 
  pilots fly adequately rested and alert thereby improving flying safety.  
E.  
eating
The stresses of flying, or indeed of any activity, consume energy. This 
energy is derived from oxygen and from blood sugar. The pilot is unwise to fly 
for too long without eating. His blood sugar will be low, that is, his energy 
reserve will be low. Reactions will be sluggish and efficiency will be impaired. 
It is a good precaution to carry a nutritious snack on long flights.
Overeating is equally as unwise as not eating. Drowsiness and excessive gas 
formation are the result of over indulgence at the dinner table just before a 
flight.
At altitudes above 5000 feet ASL, the body experiences a higher loss of water 
through the surface area of the lungs than it does at sea level. This loss 
occurs because the percentage of water vapour in a given volume of air decreases 
with altitude. Because this water loss is not accompanied by a loss of salt, as 
occurs with perspiration, there is no accompanying sensation of thirst. 
Especially on long flights at higher altitudes, it is advised therefore to have 
a drink of water every hour or so to replace the loss of body fluids.